Endocrinology and Metabolism

Original Article

Clinical Study
Eligibility for Statin Treatment in Korean Subjects with Reduced Renal Function: An Observational Study: Byung Sub Moon, Jongho Kim, Ji Hyun Kim, Young Youl Hyun, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Kyu-Beck Lee, Hyang Kim, Sung-Woo Park, Eun-Jung Rhee; Endocrinol Metab. 2016;31(3):402-409. Published online August 26, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.3.402

3,955 View
33 Download
4 Web of Science
4 Crossref

Background

The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunction using the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines in Korean adults.

Methods

Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December 2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1.73 m²; stage 2, eGFR 60 to 89 mL/min/1.73 m²; and stages 3 to 5, eGFR <60 mL/min/1.73 m². Statin eligibility in these groups was determined using the ATP III and ACC/AHA guidelines, and the risk for 10-year atherosclerotic cardiovascular disease (ASCVD) was calculated using the Framingham Risk Score (FRS) and Pooled Cohort Equation (PCE).

Results

There were 3,546 (18.9%) and 4,048 (21.5%) statin-eligible subjects according to ATP III and ACC/AHA guidelines, respectively. The proportion of statin-eligible subjects increased as renal function deteriorated. Statin eligibility by the ACC/AHA guidelines showed better agreement with the Kidney Disease Improving Global Outcomes (KDIGO) recommendations compared to the ATP III guidelines in subjects with stage 3 to 5 chronic kidney disease (CKD) (κ value, 0.689 vs. 0.531). When the 10-year ASCVD risk was assessed using the FRS and PCE, the mean risk calculated by both equations significantly increased as renal function declined.

Conclusions

The proportion of statin-eligible subjects significantly increased according to worsening renal function in this Korean cohort. ACC/AHA guideline showed better agreement for statin eligibility with that recommended by KDIGO guideline compared to ATP III in subjects with CKD.

Citations

Citations to this article as recorded by

Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus
Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E. Cooper, Fang Liu
Renal Failure.2021; 43(1): 477. CrossRef
Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
Frontiers of Medicine.2019; 13(6): 713. CrossRef
Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292. CrossRef
Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
Endocrinology and Metabolism.2017; 32(2): 274. CrossRef

Review Article

Obesity and Metabolism
Understanding Metabolomics in Biomedical Research: Su Jung Kim, Su Hee Kim, Ji Hyun Kim, Shin Hwang, Hyun Ju Yoo; Endocrinol Metab. 2016;31(1):7-16. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.7

7,007 View
127 Download
46 Web of Science
42 Crossref

Abstract PDF PubReader

The term "omics" refers to any type of specific study that provides collective information on a biological system. Representative omics includes genomics, proteomics, and metabolomics, and new omics is constantly being added, such as lipidomics or glycomics. Each omics technique is crucial to the understanding of various biological systems and complements the information provided by the other approaches. The main strengths of metabolomics are that metabolites are closely related to the phenotypes of living organisms and provide information on biochemical activities by reflecting the substrates and products of cellular metabolism. The transcriptome does not always correlate with the proteome, and the translated proteome might not be functionally active. Therefore, their changes do not always result in phenotypic alterations. Unlike the genome or proteome, the metabolome is often called the molecular phenotype of living organisms and is easily translated into biological conditions and disease states. Here, we review the general strategies of mass spectrometry-based metabolomics. Targeted metabolome or lipidome analysis is discussed, as well as nontargeted approaches, with a brief explanation of the advantages and disadvantages of each platform. Biomedical applications that use mass spectrometry-based metabolomics are briefly introduced.

Citations

Citations to this article as recorded by

Urine metabolomic biomarkers for prediction of isolated fetal congenital heart defect
Perry Friedman, Ali Yilmaz, Zafer Ugur, Faryal Jafar, Amy Whitten, Ilyas Ustun, Onur Turkoglu, Stewart Graham, Ray Bahado Singh
The Journal of Maternal-Fetal & Neonatal Medicine.2024; 35(25): 6380. CrossRef
Metabolomics and Risk of Dementia: A Systematic Review of Prospective Studies
Ashley C Flores, Xinyuan Zhang, Penny M Kris-Etherton, Martin J Sliwinski, Greg C Shearer, Xiang Gao, Muzi Na
The Journal of Nutrition.2024; 154(3): 826. CrossRef
Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations
T. Schillemans, I.A. Bergdahl, K. Hanhineva, L. Shi, C. Donat-Vargas, J. Koponen, H. Kiviranta, R. Landberg, A. Åkesson, C. Brunius
Environmental Research.2023; 216: 114570. CrossRef
UPLC-Q-Exactive-based rats serum metabolomics for characterization of traditional Chinese medicine Natures and Flavors
Hong Wang, Ruofang Gao, Jing Liu, Shuang Zhang, Yunli Zhao, Zhiguo Yu
Journal of Ethnopharmacology.2023; 302: 115931. CrossRef
Artificial Neural Networks Coupled with MALDI-TOF MS Serum Fingerprinting To Classify and Diagnose Pathological Pain Subtypes in Preclinical Models
Meritxell Deulofeu, Eladia M. Peña-Méndez, Petr Vaňhara, Josef Havel, Lukáš Moráň, Lukáš Pečinka, Anna Bagó-Mas, Enrique Verdú, Victoria Salvadó, Pere Boadas-Vaello
ACS Chemical Neuroscience.2023; 14(2): 300. CrossRef
Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC–MS-based untargeted metabolomics
Elias Iturrospe, Rani Robeyns, Katyeny Manuela da Silva, Maria van de Lavoir, Joost Boeckmans, Tamara Vanhaecke, Alexander L. N. van Nuijs, Adrian Covaci
Archives of Toxicology.2023; 97(5): 1335. CrossRef
Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus
Ya-Lei Sun, Pei-Pei Zhao, Cheng-Bi Zhu, Ming-Chen Jiang, Xin-Min Li, Jia-Lei Tao, Chan-Chan Hu, Bin Yuan
Scientific Reports.2023;[Epub] CrossRef
Comparison of Plasma Metabolites From Patients With Non-Small Cell Lung Cancer by Erlotinib Treatment and Skin Rash
Won Kil Lee, Jisoo Myong, Eunbin Kwag, Younmin Shin, Ji Woong Son, Byong Chul Yoo, Byoung-Soo Kim, Hwa-Seung Yoo, Jeong June Choi
Integrative Cancer Therapies.2023;[Epub] CrossRef
Metabolomic Signatures of Exposure to Nitrate and Trihalomethanes in Drinking Water and Colorectal Cancer Risk in a Spanish Multicentric Study (MCC-Spain)
Jose A. Alcolea, Carolina Donat-Vargas, Anastasia Chrysovalantou Chatziioannou, Pekka Keski-Rahkonen, Nivonirina Robinot, Antonio José Molina, Pilar Amiano, Inés Gómez-Acebo, Gemma Castaño-Vinyals, Lea Maitre, Marc Chadeau-Hyam, Sonia Dagnino, Sibo Lucas
Environmental Science & Technology.2023; 57(48): 19316. CrossRef
Metabolic Signature of Ethanol-Induced Hepatotoxicity in HepaRG Cells by Liquid Chromatography–Mass Spectrometry-Based Untargeted Metabolomics
Elias Iturrospe, Katyeny Manuela da Silva, Rani Robeyns, Maria van de Lavoir, Joost Boeckmans, Tamara Vanhaecke, Alexander L.N. van Nuijs, Adrian Covaci
Journal of Proteome Research.2022; 21(4): 1153. CrossRef
Current State and Challenges of the Global Outcomes of Dental Caries Research in the Meta-Omics Era
Dina G. Moussa, Paras Ahmad, Tamer A. Mansour, Walter L. Siqueira
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Current Knowledge in Skin Metabolomics: Updates from Literature Review
Alessia Paganelli, Valeria Righi, Elisabetta Tarentini, Cristina Magnoni
International Journal of Molecular Sciences.2022; 23(15): 8776. CrossRef
Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers
Donghai Liang, Jonathan Batross, Nancy Fiedler, Tippawan Prapamontol, Panrapee Suttiwan, Parinya Panuwet, Warangkana Naksen, Brittney O. Baumert, Volha Yakimavets, Youran Tan, Priya D'Souza, Ampica Mangklabruks, Supattra Sittiwang, Kristsanachai Kaewthit,
Environmental Research.2022; 215: 114319. CrossRef
Differential Plasma Metabolites between High- and Low-Grade Meningioma Cases
Gabriel A. Kurokawa, Pedro T. Hamamoto Filho, Jeany Delafiori, Aline F. Galvani, Arthur N. de Oliveira, Flávia L. Dias-Audibert, Rodrigo R. Catharino, Maria Inês M. C. Pardini, Marco A. Zanini, Estela de O. Lima, Adriana C. Ferrasi
International Journal of Molecular Sciences.2022; 24(1): 394. CrossRef
Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study
Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Åkesson, Carl Brunius
Environment International.2021; 146: 106180. CrossRef
Methionine transsulfuration pathway is upregulated in long-lived humans
Natàlia Mota-Martorell, Mariona Jové, Consuelo Borrás, Rebeca Berdún, Èlia Obis, Joaquim Sol, Rosanna Cabré, Irene Pradas, José Daniel Galo-Licona, Josep Puig, José Viña, Reinald Pamplona
Free Radical Biology and Medicine.2021; 162: 38. CrossRef
Investigating metabolism by mass spectrometry: From steady state to dynamic view
Matteo Audano, Silvia Pedretti, Simona Ligorio, Flavio Giavarini, Donatella Caruso, Nico Mitro
Journal of Mass Spectrometry.2021;[Epub] CrossRef
The Efficacy of Pilates on Urinary Incontinence in Korean Women: A Metabolomics Approach
Gyumin Kang, Haelim Lee, Malsoon Shin, Jaekwan Kim, Sungki Lee, Youngja Park
Metabolites.2021; 11(2): 118. CrossRef
Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women
Clara Eick, Johanna Klinger-König, Stephanie Zylla, Anke Hannemann, Kathrin Budde, Ann Kristin Henning, Maik Pietzner, Matthias Nauck, Henry Völzke, Hans J. Grabe, Johannes Hertel
Metabolites.2021; 11(4): 193. CrossRef
Nutritional Metabolomics and the Classification of Dietary Biomarker Candidates: A Critical Review
Talha Rafiq, Sandi M Azab, Koon K Teo, Lehana Thabane, Sonia S Anand, Katherine M Morrison, Russell J de Souza, Philip Britz-McKibbin
Advances in Nutrition.2021; 12(6): 2333. CrossRef
MSCAT: A Machine Learning Assisted Catalog of Metabolomics Software Tools
Jonathan Dekermanjian, Wladimir Labeikovsky, Debashis Ghosh, Katerina Kechris
Metabolites.2021; 11(10): 678. CrossRef
Defining NASH from a Multi-Omics Systems Biology Perspective
Lili Niu, Karolina Sulek, Catherine G. Vasilopoulou, Alberto Santos, Nicolai J. Wewer Albrechtsen, Simon Rasmussen, Florian Meier, Matthias Mann
Journal of Clinical Medicine.2021; 10(20): 4673. CrossRef
Defining Blood Plasma and Serum Metabolome by GC-MS
Olga Kiseleva, Ilya Kurbatov, Ekaterina Ilgisonis, Ekaterina Poverennaya
Metabolites.2021; 12(1): 15. CrossRef
Precision Medicine in Childhood Asthma: Omic Studies of Treatment Response
Javier Perez-Garcia, Esther Herrera-Luis, Fabian Lorenzo-Diaz, Mario González, Olaia Sardón, Jesús Villar, Maria Pino-Yanes
International Journal of Molecular Sciences.2020; 21(8): 2908. CrossRef
Metabolomic characterization of semen from asthenozoospermic patients using ultra‐high‐performance liquid chromatography–tandem quadrupole time‐of‐flight mass spectrometry
Li Li, Xinrui Hao, Hua Chen, Liyuan Wang, Aolei Chen, Xiaotian Song, Zhiyan Hu, Ying Su, Han Lin, Pei Fan
Biomedical Chromatography.2020;[Epub] CrossRef
Comparison of Metabolomic Profiles of Organs in Mice of Different Strains Based on SPME-LC-HRMS
Katarzyna Burlikowska, Iga Stryjak, Joanna Bogusiewicz, Bogumiła Kupcewicz, Karol Jaroch, Barbara Bojko
Metabolites.2020; 10(6): 255. CrossRef
Metabolomics and Machine Learning Approaches Combined in Pursuit for More Accurate Paracoccidioidomycosis Diagnoses
Estela de Oliveira Lima, Luiz Claudio Navarro, Karen Noda Morishita, Camila Mika Kamikawa, Rafael Gustavo Martins Rodrigues, Mohamed Ziad Dabaja, Diogo Noin de Oliveira, Jeany Delafiori, Flávia Luísa Dias-Audibert, Marta da Silva Ribeiro, Adriana Pardini
mSystems.2020;[Epub] CrossRef
Metabolomics in the study of spontaneous animal diseases
Helena Tran, Malcolm McConville, Panayiotis Loukopoulos
Journal of Veterinary Diagnostic Investigation.2020; 32(5): 635. CrossRef
Effect of Pioglitazone on Perihematomal Edema in Intracerebral Hemorrhage Mouse Model by Regulating NLRP3 Expression and Energy Metabolism
Hoon Kim, Jung Eun Lee, Hyun Ju Yoo, Jae Hoon Sung, Seung Ho Yang
Journal of Korean Neurosurgical Society.2020; 63(6): 689. CrossRef
Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics
Ismail, Showalter, Fiehn
Metabolites.2019; 9(10): 242. CrossRef
Metabolomic profiles of induced pluripotent stem cells derived from patients with rheumatoid arthritis and osteoarthritis
Juryun Kim, Sunyoung Christina Kang, Na Eun Yoon, Yena Kim, Jinhyeok Choi, Narae Park, Hyerin Jung, Byung Hwa Jung, Ji Hyeon Ju
Stem Cell Research & Therapy.2019;[Epub] CrossRef
Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature
Gaurav V. Sarode, Kyoungmi Kim, Dorothy A. Kieffer, Noreene M. Shibata, Tomas Litwin, Anna Czlonkowska, Valentina Medici
Metabolomics.2019;[Epub] CrossRef
Metabolomics study of the therapeutic mechanism of a Chinese herbal formula on collagen-induced arthritis mice
Zhen Jin, Ji-da Zhang, Xin Wu, Gang Cao
RSC Advances.2019; 9(7): 3716. CrossRef
Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
Seung-Soon Im, Hyeon Young Park, Jong Cheol Shon, In-Sung Chung, Ho Chan Cho, Kwang-Hyeon Liu, Dae-Kyu Song, Kyoung Heon Kim
PLOS ONE.2019; 14(3): e0213285. CrossRef
Tissue‐Specific Metabolic Profiles After Prolonged Cardiac Arrest Reveal Brain Metabolome Dysfunction Predominantly After Resuscitation
Jaewoo Choi, Muhammad Shoaib, Tai Yin, Gautam Nayyar, Koichiro Shinozaki, Jan F. Stevens, Lance B. Becker, Junhwan Kim
Journal of the American Heart Association.2019;[Epub] CrossRef
Global serum metabolomics profiling of colorectal cancer (Review)
Nurul Amir Hashim, Sharaniza Ab‑Rahim, Leny Suddin, Mohd Ahmad Saman, Musalmah Mazlan
Molecular and Clinical Oncology.2019;[Epub] CrossRef
Metabolomic Profiling of Human Spermatozoa in Idiopathic Asthenozoospermia Patients Using Gas Chromatography-Mass Spectrometry
Kai Zhao, Jianzhong Zhang, Zhen Xu, Yue Xu, Aiming Xu, Wei Chen, Chenkui Miao, Shouyong Liu, Zengjun Wang, Ruipeng Jia
BioMed Research International.2018; 2018: 1. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef
Investigation of the effects of storage and freezing on mixes of heavy‐labeled metabolite and amino acid standards
Rachel Culp‐Hill, Julie A. Reisz, Kirk C. Hansen, Angelo D'Alessandro
Rapid Communications in Mass Spectrometry.2017; 31(23): 2030. CrossRef
Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics
Darrell D. Marshall, Robert Powers
Progress in Nuclear Magnetic Resonance Spectroscopy.2017; 100: 1. CrossRef
Untargeted metabolomics analysis of adipogenic transformation in OP9‐DL1 cells using liquid chromatography‐mass spectrometry: Implications for thymic adipogenesis
Jianxin Tan, Yajun Wang, Siliang Wang, Nannan Zhang, Simeng Wu, Zhe Yuan, Xike Zhu
Cell Biology International.2017; 41(4): 447. CrossRef
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Pamela Vernocchi, Federica Del Chierico, Lorenza Putignani
Frontiers in Microbiology.2016;[Epub] CrossRef

Case Reports

A Case of Painless Thyroiditis Followed by Graves' Disease.: Gyeong Jae Na, Ji Hyun Kim, Se Yoon Park, Ki Won Kim, Hee Ja Ko, Sung Wan Jeon, Yeo Joo Kim, Sang Jin Kim; Endocrinol Metab. 2012;27(2):147-150. Published online June 20, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.2.147

2,246 View
35 Download
1 Crossref

Abstract PDF

A 30-year-old man was admitted to our hospital because of fatigue, palpitation and severe weakness of both legs. The admission laboratory findings revealed thyrotoxicosis, and 131I thyroid scintigraphic imaging revealed a low radioactive iodine uptake. He was treated for painless thyroiditis for about 4 months. However, thyrotoxic state had continued and radioactive iodine uptake was markedly increased in the follow up scan. Painless thyroiditis often relapses, but rarely develops into Graves' disease. This is a rare case in which painless thyroiditis was followed by Graves' disease.

Citations

Citations to this article as recorded by

A Case of Severe Recurrent Painless Thyroiditis Requiring Thyroidectomy
So Hyun Park, Il Seong Nam-Goong, Young Il Kim, Yun Sun Kim, Yung Min Kim, Eun Sook Kim
Journal of Korean Thyroid Association.2015; 8(1): 113. CrossRef

Papillary Thyroid Carcinoma Manifesting as an Autonomously Functioning Thyroid Nodule.: Ji Hyun Kim, Gyeong Jae Na, Ki Won Kim, Hee Ja Ko, Sung Wan Jeon, Yeo Joo Kim, Sang Jin Kim, Hyeun Duk Jo, Chang Jin Kim; Endocrinol Metab. 2012;27(1):59-62. Published online March 1, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.1.59

66,258 View
30 Download
2 Crossref

Abstract PDF

Hyperfunctioning thyroid carcinoma is very rare. Hence, radionuclide imaging of thyroid hot nodules usually suggests a benign tumor, and less than 4% of cases have been reported as malignant. We would like to present a case of a hyperfunctioning papillary thyroid carcinoma that was initially treated with radioactive iodine. A 58-year-old woman was referred to our hospital for palpable thyroid nodule and a 5-kg weight loss within 6 months. Thyroid function test revealed thyrotoxicosis, and thyroid autoantibodies were absent. 99mTc thyroid scintigraphy showed a 2 x 2 cm-sized hyperactive hot nodule at the left lobe. Despite radioactive iodine treatment with a dose of 10 mCi 131I, thyroid function did not improve. Fine needle aspiration revealed papillary thyroid cancer. The patient underwent total thyroidectomy. Although clinical features and thyroid scans suggest a benign nodule, the possibility of malignancy should not be ruled out. Malignant thyroid hot nodules are rare; however, its possibility should be taken into account. Therefore, we suggest that ruling out malignancy by existing diagnostic guidelines can misdiagnose even a typical case with benign features. As thyroid nodule detection is getting sensitive and accurate, we present this case to discuss whether additional diagnostic approaches would be necessary for thyroid nodules.

Citations

Citations to this article as recorded by

Ultrasonographic Characteristics of the Hyperfunctioning Thyroid Nodule and Predictive Factors for Thyroid Stimulating Hormone Suppression
Won Sang Yoo, Hoon Sung Choi
International Journal of Thyroidology.2019; 12(1): 35. CrossRef
Papillary Thyroid Carcinoma Presented as a Hot Nodule with Hyperthyroidism
Sung Hye Kong, Seo Young Lee, Ye Seul Yang, Jae Hoon Moon
International Journal of Thyroidology.2016; 9(1): 47. CrossRef

A Case of Ectopic Neurohypophysis Presenting with Hypogonadism.: In Woon Baek, Ji Hyun Kim, Guk Jin Lee, Kyoung Eun Lee, Hae Lim Lee, Hye Won Lee, Nam Yong Kim, Yon Kwon Ihn, Seung Hyun Ko, Seung Hwan Lee, Je Ho Han; Endocrinol Metab. 2011;26(1):67-71. Published online March 1, 2011; DOI: https://doi.org/10.3803/EnM.2011.26.1.67

2,217 View
27 Download
2 Crossref

Abstract PDF

Pituitary stalk interruption and ectopic neurohypophysis seen on magnetic resonance Imaging (MRI) are often associated with either isolated growth hormone (GH) deficiency or combined anterior pituitary hormone deficiency, but their pathogenesis is not clear and the clinical data regarding these anatomical defect is limited. We experienced a 23-year-old male with the absence of secondary sexual characteristics and this was accompanied with pituitary stalk dysgenesis and ectopic neurohypophysis. He received growth hormone for a year when he was 12 years old due to his short stature. Sella MRI showed no visible pituitary stalk with minimal high signal change, suggesting ectopic neurohypophysis. The combined pituitary stimulation test revealed blunted responses of growth hormone, follicle stimulating hormone and luteinizing hormone. For the hypogonadotropic hypogonadism, the patient was given testosterone intramuscularly and he gradually developed secondary sexual characteristics. We concluded that the hypogonadism and growth hormone deficiency in this patient was caused by hypopituitarism due to pituitary stalk dysgenesis and ecopic nuerohypophysis.

Citations

Citations to this article as recorded by

MRI of ectopic posterior pituitary gland with dysgenesis of pituitary stalk in a patient with hypogonadotropic hypogonadism
Ashim Kumar Lahiri, Ramanivas Sundareyan, David Jenkins, Anjumara Nilak
Radiology Case Reports.2018; 13(4): 764. CrossRef
Hypothalamic Hypopituitarism Caused by Pituitary Stalk Dysgenesis
Seong-Ju Lee, Hye-Jin Yoon, A-Reum Cho, Yoo-Jin Um, Keun-Young Park, Dong-Mee Lim, Byung-Joon Kim
Korean Journal of Medicine.2013; 85(4): 420. CrossRef

A Case of Sporadic Medullary Thyroid Cancer with RET G691S Polymorphism.: Min Kyu Kang, Jung Min Lee, Ji Hyun Kim, Min Young Lee, Ji Hyun Kim, Sung Dae Moon, Je Ho Han, Sang Ah Chang; J Korean Endocr Soc. 2009;24(4):293-297. Published online December 1, 2009; DOI: https://doi.org/10.3803/jkes.2009.24.4.293

1,866 View
24 Download

Abstract PDF: Sporadic medullary thyroid carcinoma (MTC) is the most common form of MTC and somatic RET proto-oncogene mutations account for approximately 25% of the patients with sporadic MTC. However, other pathogeneses of sporadic MTC are still unclear. Not only RET mutation, but also polymorphisms of RET may have an association with sporadic MTC. We herein describe the association of MTC and RET proto-oncogene polymorphism. A 51-year-old man was diagnosed with MTC, which was incidentally found on a thyroid sonogram. The patient underwent total thyroidectomy and genetic mutational analysis of the RET gene. Genetic testing detected a polymorphism in codon 691 (G691S) on exon 11 of the RET proto-oncogene. His son and daughter had the same polymorphism. We report on this case along with a review of the related literature on RET gene polymorphism of sporadic MTC.

Primary Hypogonadism Associated with Ankylosing Spondylitis.: Byoung Yeon Jun, Guk Jin Lee, Ji Hyun Kim, Jung Min Lee, Sang Ah Chang; J Korean Endocr Soc. 2008;23(5):352-357. Published online October 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.5.352

1,817 View
24 Download
2 Crossref

Abstract PDF

Male patients with hypogonadism have an increased risk of developing rheumatic diseases. Most causes of hypogonadism related with rheumatic disease are karyotype abnormality such as Klinefelter's syndrome or Turner's syndrome and gonadal dysgenesis. A 24-year-old year male was admitted for pain of both hip joints that had worsened over 2 months. He had hip joint involvement from ankylosing spondylitis and did not show secondary sex characteristics. His sex hormones and gonadotropins levels indicated hypergonadotropic hypogonadism. The karyotype was 46 XY, and there was no obvious cause of hypogonadism. Here we report on clinical features of this first Korean case of primary hypogonadism accompanying ankylosing spondylitis.

Citations

Citations to this article as recorded by

Ankylosing spondylitis associated with balanced reciprocal X-1 translocation
Young Hoon Kim, Jung Ouk Lee
Yeungnam University Journal of Medicine.2017; 34(1): 80. CrossRef
A Case of Klinefelter's Syndrome Accompanying with Polymyositis
Min Kyu Lee, Byung Sik Kim, Suk Hyun Jung, Gun Hwa Lee, Jin Ok Kim, Dong Hwi Rim, Yu Hwa Lee, Woong Jun Kim, So-Young Bang, Hye-Soon Lee
Journal of Rheumatic Diseases.2012; 19(3): 152. CrossRef

A Case of Pneumocystis Carinii Pneumonia and Cutaneous Nocardiosis Associated with Ectopic ACTH Syndrome.: Hee Sun Jung, Seung Hwan Lee, Hee Yeon Kim, Eun Ho Chu, Kang Woo Lee, Mi Ja Kang, Ji Hyun Kim, Hyuk Sang Kwon, Kun Ho Yoon, Bong Yun Cha, Ho Young Son; J Korean Endocr Soc. 2008;23(1):44-50. Published online February 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.1.44

1,765 View
19 Download

Abstract PDF: Cushing's syndrome is characterized by hypercortisolism and impairment of cell-mediated immune function, increasing the risk of opportunistic infection, as occurs in other immunocompromised groups such as organ transplant recipients, patients with lymphoreticular malignancy, or acquired immunodeficiency syndrome. We report a case of a 68-year-old woman who was affected with pneumocystis carinii pneumonia (PCP) 8 years ago and cutaneous nocardiosis this year. The patient was diagnosed with ectopic ACTH syndrome 8 years ago, but no ectopic ACTH secreting focus was found in radiologic imaging studies. She recovered from PCP and cutaneous nocardiosis after antibiotic (trimethoprim-sulfamethoxazole) administration. After the infection resolved, she underwent laparoscopic bilateral adrenalectomy and was not longer hypercortisolemic.

Diabetic Ketoacidosis in a Patient with Long-term Clozapine Therapy.: Youn Joo Jeon, Seung Hwan Lee, Se Na Jang, Eun Sun Kim, Jeong Yo Min, Ji Hyun Kim, Soon Hwa Hong, Jae Hyoung Cho, Hyuk Sang Kwon, Kun Ho Yoon, Bong Yun Cha, Ho Young Son; J Korean Endocr Soc. 2007;22(5):376-380. Published online October 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.5.376

1,778 View
20 Download
2 Crossref

Abstract PDF

With the broad use of atypical anti-psychotics, altered glucose metabolism has become an item of concern to clinicians and patients. Among the atypical anti-psychotics, clozapine and olanzapine are associated with a relatively high incidence of diabetic ketoacidosis and newly developed diabetes. We report a case of diabetic ketoacidosis in a patient with long-term clozapine therapy. A 35-year-old male with schizophrenia, treated with clozapine for 9 years was admitted into hospital because of comatous mentality. Although never diagnosed with diabetes before, his clinical features were consistent with diabetic ketoacidosis and shock. The patient's serum amylase and lipase levels were elevated and an abdominal computed tomography showed peripancreatic fat infiltration, suggesting the possibility of acute pancreatitis. The patient's serum glucose levels normalized shortly after clozapine treatment. Moreover, the patient ceased all glucose lowering agents upon hospital discharge, and maintained normal blood glucose levels thereafter. As observed in this case, clinicians should carefully screen and monitor blood glucose levels and other clinical parameters in patients treated with atypical anti-psychotics.

Citations

Citations to this article as recorded by

Two Cases of Diabetic Ketoacidosis Associated with Paliperidone Treatment in Schizophrenia
Hyun Ho Kim, Hae Kyung Yang, Hyoju Ham, Ho Wook Jeon, Joon Yub Lee, Sea Won Hwang, Bo Hyun Jang, Gi June Min, Jeong Min Lee, Seung-Hwan Lee
The Journal of Korean Diabetes.2014; 15(3): 178. CrossRef
Olanzapine-Induced Diabetic Ketoacidosis and Neuroleptic Malignant Syndrome with Rhabdomyolysis: A Case Report
Young Kyoung Sa, Hyeon Yang, Hee Kyoung Jung, Jang Won Son, Seong Su Lee, Seong Rae Kim, Bong Yeon Cha, Ho Young Son, Chi-Un Pae, Soon Jib Yoo
Endocrinology and Metabolism.2013; 28(1): 70. CrossRef

A Patient with Concurrent Medullary and Papillary Carcinoma of the Thyroid.: Seung Hee Yoo, Keun Joon Lim, Seung Hwan Lee, Ji Hyun Kim, Soon Hwa Hong, Jae Hyoung Cho, Chan Kwon Jung, Hyuk Sang Kwon, Kun Ho Yoon, Min Sik Kim, Bong Yun Cha, Ho Young Son; J Korean Endocr Soc. 2007;22(3):235-240. Published online June 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.3.235

1,868 View
19 Download
1 Crossref

Abstract PDF

The origin of medullary thyroid carcinoma and papillary thyroid carcinoma are embryogenically different, so these tumors have been thought to be independent of each other. We experienced a case of concurrent medullary and papillary thyroid carcinoma in one patient. The patient underwent total thyroidectomy and both two tumors were located at different lobes, respectively. Both tumors showed their own characteristic pathologic and immunohistochemical findings. The patient's elevated calcitonin level returned to the normal range after operation and there has been no evidence of recurrence. It is still controversial whether the concurrency is just coincidental or it arises from activation of a common tumorigenic pathway.

Citations

Citations to this article as recorded by

A Case of Concurrent Papillary and Medullary Thyroid Carcinomas Detected as Recurrent Medullary Carcinoma after Initial Surgery for Papillary Carcinoma
Dongbin Ahn, Jin Ho Sohn, Ji Young Park
Journal of Korean Thyroid Association.2013; 6(1): 80. CrossRef

A Case of Pituitary Metastasis of Breast Cancer Presenting as Diabetes Insipidus and Panhypopituitarism.: Jae Wuk Kwak, Byung Soo Jie, Sun Hwa Hong, Ji Hyun Kim, Seung Hwan Lee, Jae Hyung Jo, Hyuk Sang Kwon, Kun Ho Youn, Bong Yun Cha, Ho Young Son; J Korean Endocr Soc. 2007;22(2):125-129. Published online April 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.2.125

2,251 View
21 Download
2 Crossref

Abstract PDF

Metastasis to the pituitary gland from systemic cancer is a rare condition. The breast and lung are the most common sites of primary tumor metastasis. Pituitary metastasis may present with diabetes insipidus, cranial nerve palsy and hypopituitarism, and diabetes insipidus is the most frequent symptom at presentation. We report here on a 44 year-old woman with pituitary metastasis from breast cancer, and she developed central diabetes insipidus and hypopituitarism. The clinical diagnosis was made by performing a water deprivation test, a combined pituitary test and a MRI brain scan, and the latter showed metastatic tumor in the pituitary gland with invasion of the pituitary stalk. Symptomatic relief was obtained with administration of desmopressin; the urine osmolarity was increased with this treatment. We report here on a case of pituitary metastasis from breast cancer and the patient developed central diabetes insipidus and hypopituitarism. We also include a review of the relevant literature.

Citations

Citations to this article as recorded by

A Case of Pituitary Metastasis from Breast Cancer That Presented as Left Visual Disturbance
Young Ha Kim, Beom jun Lee, Kyung Jin Lee, Jin Hee Cho
Journal of Korean Neurosurgical Society.2012; 51(2): 94. CrossRef
A Case of Panhypopituitarism and Central Diabetes Insipidus Caused by Primary Central Nervous System Lymphoma
Mi Sun Ahn, Soon Sun Kim, Tae Ho Kim, Seung Jin Han, Dae Jung Kim, Hugh Chul Kim, Se Hyuk Kim, Jae Ho Han, Ho Sung Kim, Yoon-Sok Chung
Journal of Korean Endocrine Society.2008; 23(4): 260. CrossRef

First
Prev
Page of 1
Next
Last

Search